Recombinant Human OSMRB (C-6His)

Description

EnkiLife provides the Recombinant Human OSMRB (C-6His) protein,aslo know as Oncostatin-M-Specific Receptor Subunit Beta,Interleukin-31 Receptor Subunit Beta,IL-31 Receptor Subunit Beta,IL-31R Subunit Beta,IL-31R-Beta,IL-31RB,OSMR,OSMRB, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Oncostatin-M-Specific Receptor Subunit Beta is produced by our Mammalian expression system and the target gene encoding Glu28-Ser739 is expressed with a 6His tag at the C-terminus.Accession:Q99650. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:82.03 KDa. Background:Oncostatin-M-Specific Receptor Subunit β (OSMRβ) is a 150 - 180 kDa member of the IL-6 receptor family. OSMRβ associates with gp130 to form the type II OSM receptor, the receptor is responsive to OSM. Gp130 subunit is shared by other IL-6 family cytokine receptors, and OSMRβ associates with gp130-like receptor (GPL) to form a receptor complex responsive to IL-31. The human OSMRβ cDNA encodes a 979 amino acid (aa) precursor, the precursor includes a 27 aa signal sequence, a 712 aa extracellular domain (ECD), a 22 aatransmembrane segment, and a 218 aa cytoplasmic domain. The ECD contains one partial and one complete hematopoietin domain, an Ig-like domain, and three Fibronectin type-III domains.