Recombinant Human PDCD4 (C-6His)

Description

EnkiLife provides the Recombinant Human PDCD4 (C-6His) protein,aslo know as Programmed Cell Death Protein 4,Neoplastic Transformation Inhibitor Protein,Nuclear Antigen H731-Like,Protein 197/15a,PDCD4,H731, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Programmed Cell Death Protein 4 is produced by our E.coli expression system and the target gene encoding Lys212-Pro357 is expressed with a 6His tag at the C-terminus.Accession:Q53EL6. Expression Host:E.coli.Species:Human.Predicted Molecular Mass:17 KDa. Background:Programmed Cell Death Protein 4 (PDCD4) is a member of the PDCD4 family. PDCD4 and EIF4A1 form a heterotrimer. One molecule of PDCD4 binds two molecules of EIF4A1. PDCD4 takes part in apoptosis via inhibiting translation initiation and cap-dependent translation.PDCD4 promotes colonic neoplastic transformation and tumor invasion. PDCD4 is an important target for microrna R-21 in breast cancer cells. Shortage of PDCD4 expression is associated with colorectal cancer. Overexpression of PDCD4 in carcinoid cells results in inhibition of cell proliferation.