Recombinant Human PKLR (C-6His)

Description

EnkiLife provides the Recombinant Human PKLR (C-6His) protein,aslo know as Pyruvate Kinase Isozymes R/L,Pyruvate Kinase 1,R-Type/L-Type Pyruvate Kinase,Red Cell/Liver Pyruvate Kinase,PKLR,PK1,PKL, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Pyruvate Kinase, Liver And RBC is produced by our Mammalian expression system and the target gene encoding Met1-Ser574 is expressed with a 6His tag at the C-terminus.Accession:P30613. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:62.9 KDa. Background:Pyruvate Kinase Isozymes R/L (PKLR) belongs to the pyruvate kinase family, There are 4 isozymes of pyruvate kinase in mammals: L, R, M1 and M2. L type is major isozyme in the liver; R is found in red cells; M1 is the main form in muscle, heart and brain; M2 is found in early fetal tissues. PKLR exists as a homotetramer and catalyzes the production of phosphoenolpyruvate from pyruvate and ATP. Defects in PKLR are also the cause of pyruvate kinase deficiency of red cells, which is a frequent cause of hereditary non-spherocytic hemolytic anemia.