Recombinant Human PPM1A (C-6His)

Description

EnkiLife provides the Recombinant Human PPM1A (C-6His) protein,aslo know as Protein Phosphatase 1A,Protein Phosphatase 2C Isoform Alpha,PP2C-Alpha,Protein Phosphatase IA,PPM1A,PPPM1A, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Protein Phosphatase 1A is produced by our E.coli expression system and the target gene encoding Gly2-Trp382 is expressed with a 6His tag at the C-terminus.Accession:P35813. Expression Host:E.coli.Species:Human.Predicted Molecular Mass:43.5 KDa. Background:Protein Phosphatase 1A (PPM1A) is a member of the PP2C family of Ser/Thr protein phosphatases which are known to be negative regulators of cell stress response pathways. PPM1A has a broad specificity. PPM1A negatively regulates the activities of MAP kinases and MAP kinase kinases. Also, it negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. In addition, PPM1A can dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control.