Recombinant Human PPP1R1A (C-6His)

Description

EnkiLife provides the Recombinant Human PPP1R1A (C-6His) protein,aslo know as Protein Phosphatase 1 Regulatory Subunit 1A,Protein Phosphatase Inhibitor 1,I-1,IPP-1,PPP1R1A,IPP1, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Protein Phosphatase 1 Regulatory Subunit 1A is produced by our E.coli expression system and the target gene encoding Met1-Val171 is expressed with a 6His tag at the C-terminus.Accession:AAH22470.1. Expression Host:E.coli.Species:Human.Predicted Molecular Mass:19.98 KDa. Background:Protein Phosphatase 1 Regulatory Subunit 1A (PPP1R1A) is an inhibitor of protein-phosphatase 1. PPP1R1A is a cellular regulator of eIF2 alpha phosphorylation. In hormonal control of glycogen metabolism, IPP-1 protein plays important function. Hormones can elevate intracellular cAMP level and elevate IPP-1 activity. PPP1R1A activation caused cAMP increase , cAMP control over proteins that are not directly phosphorylated by PKA following a rise in intracellular calcium. IPP-1 is inactivated by calcineurin (PP2B). Multiple domains in IPP-1 target cellular PP1 complexes.