Recombinant Human PRG3 (C-6His)

Description

EnkiLife provides the Recombinant Human PRG3 (C-6His) protein,aslo know as Proteoglycan 3,Eosinophil Major Basic Protein Homolog,Prepro-Major Basic Protein Homolog,Prepro-MBPH,PRG3,MBPH, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Proteoglycan 3 is produced by our Mammalian expression system and the target gene encoding Leu18-Phe225 is expressed with a 6His tag at the C-terminus.Accession:AAI13412.1. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:24.6 KDa. Background:Proteoglycan 3, also known as Eosinophil major basic protein homolog, Prepro-major basic protein homolog, PRG3 and MBPH, contains one C-type lectin domain. Proteoglycans are a major component of the animal extracellular matrix. PRG3 localizes to the eosinophil secondary granule and is expressed in bone marrow, not detected in placenta. PRG3 has similar cytotoxic and cytostimulatory activities to PRG2/MBP. In vitro, PRG3 can stimulate neutrophil superoxide production and IL8 release, histamine and leukotriene C4 release from basophils.