Recombinant Human PRKG1 (C-6His)

Description

EnkiLife provides the Recombinant Human PRKG1 (C-6His) protein,aslo know as cGMP-Dependent Protein Kinase 1,cGK 1,cGK1,cGMP-Dependent Protein Kinase I,cGKI,PRKG1,PRKG1B,PRKGR1A,PRKGR1B, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human cGMP-Dependent Protein Kinase 1 is produced by our Mammalian expression system and the target gene encoding Gly2-Phe686 is expressed with a 6His tag at the C-terminus.Accession:Q13976-2. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:78.8 KDa. Background:cGMP-Dependent Protein Kinase 1 (PRKG1) belongs to the protein kinase superfamily and AGC Ser/Thr protein kinase family. PRKG1 contains one AGC-kinase C-terminal domain, two cyclic nucleotide-binding domains, and one protein kinase domain. PRKG1 is mainly expressed in the lung and placenta. PRKG1 acts as a key mediator of the nitric oxide (NO)/cGMP signaling pathway. PRKG1 can phosphorylate many proteins that regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of the NO-signaling pathway, and other processes involved in several aspects of the CNS like axon guidance, hippocampal and cerebellar learning, circadian rhythm, and nociception.