Recombinant Human proHB-EGF (C-6His)

Description

EnkiLife provides the Recombinant Human proHB-EGF (C-6His) protein,aslo know as Diphtheria toxin receptor,DTR;HEGFL,heparin-binding EGF-like growth factor,DTS,DTSF,heparin-binding epidermal growth factor,proheparin-binding EGF-like growth factor,HB-EGF,pro HB-EGF, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Heparin Binding EGF like Growth Factor is produced by our Mammalian expression system and the target gene encoding Leu20-Leu148 is expressed with a 6His tag at the C-terminus.Accession:Q99075. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:15.1 KDa. Background:Heparin-binding EGF-like growth factor (HB-EGF) is a 12/xad16 kDa member of the epidermal growth factor (EGF) family. It possesses an EGF/xadlike domain, and a heparin-binding motif. Mature HB/xadEGF is a soluble peptide that arises from proteolytic processing of the transmembrane form. Human HB/xadEGF shows 76% and 73% aa sequence identity with rat and mouse HB/xadEGF, respectively. It is required for normal cardiac valve formation and normal heart function, promotes smooth muscle cell proliferation. It may be involved in macrophage-mediated cellular proliferation; it is mitogenic for fibroblasts, but not endothelial cells. HB/xadEGF classified as a group 2 ErbB ligand based on its ability to activate both the EGF/ErbB1 and ErbB4 receptors. Activity associated with ErbB4 binding appears to be limited to non/xadmitogenic actions, while EGFR binding induces both mitogenic and non/xadmitogenic activity.