Recombinant Human PRTN3 (C-6His)

Description

EnkiLife provides the Recombinant Human PRTN3 (C-6His) protein,aslo know as Myeloblastin,AGP7,C-ANCA Antigen,Leukocyte Proteinase 3,PR-3,PR3,Neutrophil Proteinase 4,NP-4,P29,Wegener Autoantigen,PRTN3,MBN, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Proteinase 3 is produced by our Mammalian expression system and the target gene encoding Ala26-Arg249 is expressed with a 6His tag at the C-terminus.Accession:P24158. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:25.64 KDa. Background:Proteinase-3 is a neutral serine proteinase that belongs to the peptidase S1 family and Elastase subfamily. It contains one peptidase S1 domain and it is expressed mainly in neutrophil granulocytes. The primary function of Proteinase-3 is thought to be degradation of extracellular proteins at sites of inflammation, but excessive or prolonged proteolytic activity may cause harmful effects in the body. It is the epitope of anti-neutrophil cytoplasmic antibodies (ANCAs) of the cANCA (cytoplasmic subtype) class, a type of antibody frequently found in the disease Wegeners granulomatosis.