Recombinant Human PSGL-1 (C-Fc)

Description

EnkiLife provides the Recombinant Human PSGL-1 (C-Fc) protein,aslo know as P-selectin glycoprotein ligand 1,PSGL-1,Selectin P ligand,CD162,SELPLG, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human P-selectin Glycoprotein Ligand 1 is produced by our Mammalian expression system and the target gene encoding Gln42-Gly295 is expressed with a human IgG1 Fc tag at the C-terminus.Accession:Q14242. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:52.9 KDa. Background:PSGL-1 (CD162), is a mucintype glycoprotein that plays a key role in leukocyte adhesion. Human PSGL-1 cDNA encodes 412 amino acids (aa). It expressed on neutrophils, monocytes and most lymphocytes. The mature PSGL-1 (aa 42-412) is expressed as a disulfide-linked homodimer that signals intracellularly and promotes integrin activation. PSGL-1 is found on virtually all leukocytes, dendritic cells, platelets, and some endothelial cells. It is primarily responsible for early events in extravasation, especially rolling adhesion of leukocytes to vascular endothelium. Through high affinity, This SLe(x)-type proteoglycanPGSL-1 calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation.