Recombinant Human PTGDS (C-6His)

Description

EnkiLife provides the Recombinant Human PTGDS (C-6His) protein,aslo know as Prostaglandin-H2 D-Isomerase,Beta-Trace Protein,Cerebrin-28,Glutathione-Independent PGD Synthase,Lipocalin-Type Prostaglandin-D Synthase,Prostaglandin-D2 Synthase,PGD2 Synthase;PGDS,PGDS2,PTGDS,PDS, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Prostaglandin-D2 Synthase is produced by our Mammalian expression system and the target gene encoding Ala23-Gln190 is expressed with a 6His tag at the C-terminus.Accession:P41222. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:19.7 KDa. Background:Prostaglandin-H2 D-Isomerase (PTGDS) belongs to the Lipocalin family of calycin superfamily. PTGDS is preferentially expressed in the brain. PTGDS catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. PTGDS is involved in a variety of CNS functions, such as sedation, REM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. PTGDS binds small non-substrate lipophilic molecules and may act as a scavenger for harmful hydrophopic molecules and a secretory retinoid and thyroid hormone transporter. It possibly participates in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor, blood-testis barrier, the central nervous system and male reproductive system.