Recombinant Human PVRIG (C-mFc)

Description

EnkiLife provides the Recombinant Human PVRIG (C-mFc) protein,aslo know as C7orf15,CD112R,PVRIG,transmembrane protein PVRIG,C7orf15MGC138295,MGC104322,MGC138297,MGC2463, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Transmembrane Protein PVRIG is produced by our Mammalian expression system and the target gene encoding Thr41-Asp171 is expressed with a mouse IgG1 Fc tag at the C-terminus.Accession:Q6DKI7. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:40.1 KDa. Background:Human PVRIG (poliovirus receptor related immunoglobulin domain-containing protein), also known as CD112 receptor (CD112R), is an approximately 34 kDa single transmembrane protein in the poliovirus receptor-like protein (PVR) family. The extracellular domain sequence of human and mouse PVRIG have approximately 65% similarity. PVRIG functions as a cell surface receptor for Nectin-2/CD112, a cell surface protein that is widely expressed on antigen-presenting cells and tumor cells. Disrupting the PVRIG/Nectin-2 interaction enhances human T cell response, suggesting PVRIG is a novel checkpoint for human T cells. PVRIG may act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals.