Recombinant Human RANK L (N-6His-Flag)

Description

EnkiLife provides the Recombinant Human RANK L (N-6His-Flag) protein,aslo know as CD254,ODF,OPGL,RANK L,TNFSF11,CD254,Osteoclast differentiation factor,Receptor activator of nuclear factor kappa-B ligand,tumor necrosis factor ligand superfamily member 11, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<0.01 EU/µg as determined by LAL test.;Construction:Recombinant Human Tumor necrosis factor ligand superfamily member 11 is produced by our Mammalian expression system and the target gene encoding Ile140-Asp317 is expressed with a 6His, Flag tag at N-terminus.Accession:O14788. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:25.3 kDa. Background:CD254, also known as RANKL, TNFSF11, TRANCE, OPGL and ODF, is a type II membrane protein of the tumor necrosis factor (TNF) superfamily, and affects the immune system and control bone regeneration and remodeling. RANKL is the ligand of nuclear factor (NF)-κB (RANK). When RANKL binds to RANK, it will undergo trimerization and then bind to an adaptor molecule TNF receptor-associated factor 6 (TRAF6). This results in the activation of several downstream signaling cascades, including the NFκB, mitogen-activated protein kinases (MAPK), activating protein 1 (AP-1), and nuclear factor of activated T cells (NFATc1), resulting in the formation of multinucleated bone-resorbing osteoclasts. RANKL is widely expressed in skeletal muscle, thymus, liver, colon, small intestine, adrenal gland, osteoblast, mammary gland epithelial cells, prostate and pancreas.