Recombinant Human RRM2 (C-6His)

Description

EnkiLife provides the Recombinant Human RRM2 (C-6His) protein,aslo know as Ribonucleoside-Diphosphate Reductase Subunit M2,Ribonucleotide Reductase Small Chain,Ribonucleotide Reductase Small Subunit,RRM2,RR2, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Ribonucleotide Reductase Small Chain is produced by our Mammalian expression system and the target gene encoding Met1-Phe389 is expressed with a 6His tag at the C-terminus.Accession:P31350. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:45.9 KDa. Background:Ribonucleoside-Diphosphate Reductase Subunit M2 (RRM2) belongs to the ribonucleoside diphosphate reductase small chain family. The reductase of RRM2 catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. RRM2 supplies the precursors essential for DNA synthesis. RRM2 catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Phosphorylation on Ser-20 relieves the inhibitory effect on Wnt signaling.