Recombinant Human RSPO3 (C-6His)

Description

EnkiLife provides the Recombinant Human RSPO3 (C-6His) protein,aslo know as R-spondin-3,RSPO3,Protein with TSP type-1 repeat,Roof plate-specific spondin-3,Thrombospondin type-1 domain-containing protein 2,PWTSR,THSD2,CRISTIN1, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human R-Spondin 3 is produced by our Mammalian expression system and the target gene encoding Gln22-Val146 is expressed with a 6His tag at the C-terminus.Accession:Q9BXY4. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:14.7 kDa. Background:R-spondin-3 (RSPO3), also known as Protein with TSP type-1 repeat, Roof plate-specific spondin-3, Thrombospondin type-1 domain-containing protein 2, PWTSR, THSD2 and CRISTIN1, is a member of the thrombospondin type 1 repeat supergene family. RSPO3 is a secreted protein and widely expressed in many tissues. RSPO3 contains two Furin-like repeats which have been found in a variety of eukaryotic proteins involved in the mechanism of signal transduction by receptor tyrosine kinases, and one TSP type-1 domain, RSPO3 founctions as a activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Otherwise, RSPO3 may negatively regulate the TGF-beta pathway.