Recombinant Human S100A7

Description

EnkiLife provides the Recombinant Human S100A7 protein,aslo know as Protein S100-A7,Psoriasin,S100 calcium-binding protein A7,S100A7,PSOR1,S100A7C, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Protein S100-A7 is produced by our E.coli expression system and the target gene encoding Met1-Gln101 is expressed.Accession:P31151. Expression Host:E.coli.Species:Human.Predicted Molecular Mass:11.5 KDa. Background:S100A7 is a 11-12 kDa member of the S100 family of EF hand calcium binding proteins. Human S100A7 shares 32% amino acid sequence identity with mouse S100A7A, the closest related protein in mouse. It is acetylated at the N-terminus and binds both calcium and zinc ions. S100A7 is up-regulated in keratinocytes of psoriasis and atopic dermatitis lesions, as well as in epithelial cells of the tongue, eye, and female genital tract. Its up-regulation can be induced by bacterial exposure, inflammatory cytokines, or epidermal barrier disruption. S100A7 supports epithelial integrity through killing E. coli by sequestration of zinc and through inducing the up-regulation of tight junction proteins. The interaction of S100A7 with RAGE promotes the migration of immune cells and the infiltration of macrophages into tumor sites.