Recombinant Human sCD4 (C-Fc)

Description

EnkiLife provides the Recombinant Human sCD4 (C-Fc) protein,aslo know as T-cell surface glycoprotein CD4,T-cell surface antigen T4/Leu-3,CD4,Scd4, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human T-cell Surface Glycoprotein CD4 is produced by our Mammalian expression system and the target gene encoding Lys26-Trp390 is expressed with a human IgG1 Fc tag at the C-terminus.Accession:P01730. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:67.6 KDa. Background:CD4 is an approximately 55/xa0kDa type/xa0I transmembrane glycoprotein that is expressed predominantly on thymocytes and a subset of mature T/xa0lymphocytes. It is a standard phenotype marker for the identification of T/xa0cell populations. Mature human CD4 consists of a 371/xa0amino acid extracellular region containing four immunoglobulin-like domains, a 22/xa0aa transmembrane segment, and a 40/xa0aa cytoplasmic domain. CD4 is expressed along with CD8 on double positive T/xa0cells during their development in the thymus. CD4 binds directly to MHC class/xa0II molecules on antigen presenting cells (10). This interaction contributes to the formation of the immunological synapse which is focused around the TCR-MHC class II-antigenic peptide interaction. CD4 also functions as a chemotactic receptor for IL-16 and, in human, as a co-receptor for the gp120 surface glycoprotein of HIV-1.