Recombinant Human Serpin A6 (C-6His)

Description

EnkiLife provides the Recombinant Human Serpin A6 (C-6His) protein,aslo know as Corticosteroid-Binding Globulin,CBG,Serpin A6,Transcortin,SERPINA6,CBG, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Serine Protease Inhibitor-clade A6 is produced by our Mammalian expression system and the target gene encoding Met23-Val405 is expressed with a 6His tag at the C-terminus.Accession:AAH58021.1. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:43.67 KDa. Background:Serpin Peptidase Inhibitor, Clade A, Member 6 (SerpinA6) belongs to the Serine Protease Inhibitors superfamily. SerpinA6 is synthesized in liver and has also been identified in a number of glycocorticoid responsive cells. SerpinA6 has an alpha-globulin protein with corticosteroid-binding properties. It is the major transport protein for glucocorticoids and progestins in the blood of most vertebrates. Defects in SERPINA6 are a cause of corticosteroid-binding globulin deficiency which is an extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration, and normal or low basal cortisol levels associated with hypo/hypertension and muscle fatigue.