Recombinant Human Serpin E2 (C-6His)

Description

EnkiLife provides the Recombinant Human Serpin E2 (C-6His) protein,aslo know as Glia-derived Nexin,GDN,Peptidase inhibitor 7,PI-7,Protease nexin 1,PN-1,Protease nexin I,Serpin E2,SERPINE2,PI7,PN1, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Glia-derived Nexin is produced by our Mammalian expression system and the target gene encoding Ser20-Pro397 is expressed with a 6His tag at the C-terminus.Accession:P07093-2. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:42.7 KDa. Background:Serpin E2 is a secreted protein that belongs to the serpin family. Serpin E2 is a serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Serpin E2 expression is weak or absent in all normal pancreas and chronic pancreatitis tissue. In contrast, it was strongly over-expressed in the majority of pancreatic carcinoma as well as gastric and colorectal cancer samples. Serpin E2 promotes neurite extension by inhibiting thrombin. It also can bind heparin. It has been shown that Serpin E2 is a novel target of ERK signaling involved in human colorectal tumorigenesis. It plays an important role in controlling male fertility because its knockout male mice show a marked impairment in fertility from the onset of sexual maturity and its abnormal expression is found in the semen of men with seminal dysfunction.