Recombinant Human Sialidase-1 (C-6His)

Description

EnkiLife provides the Recombinant Human Sialidase-1 (C-6His) protein,aslo know as Sialidase-1,Acetylneuraminyl Hydrolase,G9 Sialidase,Lysosomal Sialidase,N-Acetyl-Alpha-Neuraminidase 1,NEU1,NANH, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human N-acetyl-alpha-Neuraminidase 1 is produced by our Mammalian expression system and the target gene encoding Glu48-Leu415 is expressed with a 6His tag at the C-terminus.Accession:Q99519. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:41.27 KDa. Background:Sialidase-1 belongs to the N-acetyl-a neuraminidase family. Sialidase-1 is expressed in many tissues; it is highly expressed in the pancreas, and weakly expressed in the brain. Sialidase-1 is a lysosomal enzyme, which cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. Deficiencies in the human enzyme Sialidase-1 leads to sialidosis, a rare lysosomal storage disease. Sialidase-1 has been shown to interact with Cathepsin A (protective protein), β-galactosidase and N-acetylgalactosamine-6-sulfate sulfatase in a multienzyme complex.