Recombinant Human Siglec-7 (C-6His)

Description

EnkiLife provides the Recombinant Human Siglec-7 (C-6His) protein,aslo know as siglec-7,AIRM1,AIRM-1,AIRM1QA79 membrane protein,CD328 antigen,CD328,CDw328,D-siglec,p75,p75/AIRM1,QA79,sialic acid binding Ig-like lectin 7,sialic acid-binding Ig-like lectin 7,Siglec7,Siglec-7, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Sialic Acid-binding Ig-like Lectin 7 is produced by our Mammalian expression system and the target gene encoding Gln19-Leu353 is expressed with a 6His tag at the C-terminus.Accession:Q9Y286. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:37.8 KDa. Background:Siglecs (sialic acid binding Ig-like lectins) are I-type (Ig-type) lectins belonging to the Ig superfamily. They are characterized by an N-terminal Ig-like V-type domain which mediates sialic acid binding, followed by varying numbers of Ig-like C2-type domains. Eleven human Siglecs have been cloned and characterized. Human Siglec-7 encodes a 467 amino acid (aa) polypeptide with a hydrophobic signal peptide, an N-terminal Ig-like V-type domain, two Ig-like C2-type domains, a transmembrane region and a cytoplasmic tail. Siglec-7 exists as a monomer on the cell surface and is expressed on natural killer cells, CD8+ T cells and monocytes. It binds equally well to both alpha 2,3- and alpha 2,6-linked sialic acid. The gene encoding Siglec-7 was mapped to chromosome 19q13.3.