Recombinant Human SIRPB2 (C-Fc)

Description

EnkiLife provides the Recombinant Human SIRPB2 (C-Fc) protein,aslo know as dJ776F14.2,PTPN1L,PTPNS1L3,Signal-Regulatory Protein Beta 2,Signal-Regulatory Protein Beta-2,SIRP beta 2,SIRP-beta-2,SIRPG, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Signal-regulatory Protein Beta-2 is produced by our Mammalian expression system and the target gene encoding Gln33-Gly287 is expressed with a human IgG1 Fc tag at the C-terminus.Accession:Q5JXA9. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:55.2 KDa. Background:Signal-regulatory protein beta-2(SIRP-beta-2), is a monomeric single pass type I membrane glycoprotein, belongs to the SIRP/SHPS (CD172) family of the immunoglobulin (Ig) superfamily. The SIRP family are paired receptors that have similar extracellular domains but differing C-terminal domains and functions. A positively charged residue within the transmembrane domain, in analogy to SIRP-beta-1, is implicated to mediate interaction with the adaptor DAP12 protein, which contains immunoreceptor tyrosine-based activation motifs (ITAMs) . Proteins in the SIRP family are typically expressed in immune cells, especially in the myeloid lineages . Based on expression patterns, SIRPs are thought to have roles in immune regulation. SIRP family members role in innate immunity and host defense has potential significance as a therapeutic target in cancer and inflammation. There are currently no known mouse or rat homologs for this protein.