Recombinant Human SMAD4 (C-6His)

Description

EnkiLife provides the Recombinant Human SMAD4 (C-6His) protein,aslo know as Mothers Against Decapentaplegic Homolog 4,MAD Homolog 4,Mothers Against DPP Homolog 4,Deletion Target in Pancreatic Carcinoma 4,SMAD Family Member 4,SMAD 4,Smad4,hSMAD4,SMAD4,DPC4,MADH4, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Mothers Against Decapentaplegic Homolog 4 is produced by our E.coli expression system and the target gene encoding Met1-Asp552 is expressed with a 6His tag at the C-terminus.Accession:Q13485. Expression Host:E.coli.Species:Human.Predicted Molecular Mass:61.5 KDa. Background:SMAD Family Member 4 (SMAD4) is a cytoplasmic protein that belongs to the Dwarfin/SMAD family. SMAD4 contains one MH1 (MAD homology 1) domain and one MH2 (MAD homology 2) domain. It is the component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. SMAD4 promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. SMAD4 may act as a tumor suppressor. It positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. Mutations or deletions in SMAD4 have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome.