Recombinant Human STAT6 (C-6His)

Description

EnkiLife provides the Recombinant Human STAT6 (C-6His) protein,aslo know as Signal Transducer and Activator of Transcription 6,IL-4 Stat,STAT6, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Signal Transducer And Activator Of Transcription 6 is produced by our E.coli expression system and the target gene encoding Ser627-Ser837 is expressed with a 6His tag at the C-terminus.Accession:P42226. Expression Host:E.coli.Species:Human.Predicted Molecular Mass:23.9 KDa. Background:Signal Transducer and Activator of Transcription 6 (STAT6) is a member of the STAT family of transcription factors. At least seven STATs exist: STAT1, 2, 3, 4, 5a, 5b, and 6. They are responsible for an array of cellular activities including regulating growth, survival, differentiation, motility, and the immune response. STAT6 plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. STAT6 has been shown to interact with EP300, CREB-binding protein, NFKB1, Nuclear receptor coactivator 1, IRF4 and SND1.