Recombinant Human Stathmin (C-6His)

Description

EnkiLife provides the Recombinant Human Stathmin (C-6His) protein,aslo know as Stathmin,Leukemia-Associated Phosphoprotein p18,Metablastin,Oncoprotein 18,Op18,Phosphoprotein p19,pp19,Prosolin,Protein Pr22,pp17,STMN1,C1orf215,LAP18,OP18, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Stathmin is produced by our E.coli expression system and the target gene encoding Ala2-Asp149 is expressed with a 6His tag at the C-terminus.Accession:P16949. Expression Host:E.coli.Species:Human.Predicted Molecular Mass:18.37 KDa. Background:Stathmin (STMN1) is a ubiquitous cytosolic phosphoprotein which belongs to the Stathmin family. STMN1 is expressed in many tissues, with the highest expression in the brain, spinal cord, and cerebellum. It can also be expressed in the colon, ovary, placenta, uterus, and trachea. STMN1 participates in the regulation of the microtubule filament structure by destabilizing microtubules. STMN1 promotes the disassembly of microtubules and prevents assembly. STMN1 is involved in the control of the learned and innate fear. STMN1 is an intracellular relay integrating regulatory signals of the cellular environment and as an Oncoprotein in regulation of the cell cycle. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Mutation in STMN1 effects cell homeostasis that may lead to tumorigenicity.