Recombinant Human Tau-D (C-6His)

Description

EnkiLife provides the Recombinant Human Tau-D (C-6His) protein,aslo know as Microtubule-Associated Protein Tau,Neurofibrillary Tangle Protein,Paired Helical Filament-Tau,PHF-Tau,MAPT,MAPTL,MTBT1,TAU, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Microtubule-Associated Protein Tau-D is produced by our E.coli expression system and the target gene encoding Gln249-Gln381 is expressed with a 6His tag at the C-terminus.Accession:P10636-6. Expression Host:E.coli.Species:Human.Predicted Molecular Mass:15.37 KDa. Background:Microtubule-Associated Protein TAU is abundantly expressed in neurons of the central nervous system and less commonly expressed elsewhere, but is also expressed at very low levels in CNS astrocytes and oligodendrocytes. Tau interacts with tubulin to stabilize microtubules and promotes tubulin assembly into microtubules. The C-terminus of TAU binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau acts as a linker protein. When tau is defective, and no longer stabilize microtubules properly, it can result in dementias such as Alzheimers disease and other tauopathies.