Recombinant Human TGF-β3

Description

EnkiLife provides the Recombinant Human TGF-β3 protein,aslo know as Transforming growth factor beta-3, TGFB3, TGF-beta-3, Latency-associated peptide, LAP, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:≤10 EU/mg;Construction:Recombinant Human TGF-β3 is produced by our Mammalian cell expression system and the target gene encoding Ala 301-Ser 412 is expressed.Accession:P10600. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:13 kDa. Background:Transforming growth factor beta 3(TGFB3) is a member of a TGF -β superfamily which is defined by theirstructural and functional similarities. TGFB3 is secreted as a complex with LAP. This latent form of TGFB3becomes active upon cleavage by plasmin, matrix metalloproteases, thrombospondin -1, and a subset ofintegrins. It binds with high affinity to TGF- β RII, a type II serine/threonine kinase receptor. TGFB3 is involved incell differentiation, embryogenesis and development.It is believed to regulate molecules involved in cellularadhesion and extracellular matrix (ECM) formation during the process of palate development. Without TGF-β3,mammals develop a deformity known as a cleft palate.