Recombinant Human Tie-2 (C-6His)

Description

EnkiLife provides the Recombinant Human Tie-2 (C-6His) protein,aslo know as angiopoietin-1 receptor,CD202b antigen,CD202b,EC 2.7.10,EC 2.7.10.1,hTIE2,p140 TEK,soluble TIE2 variant 1,soluble TIE2 variant 2,TEK tyrosine kinase, endothelial,TEK,Tie2,Tie-2,VMCM,VMCM1, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Tie-2 is produced by our Mammalian expression system and the target gene encoding Ala23-Lys745 is expressed with a 6His tag at the C-terminus.Accession:NP_000450.2. Expression Host:Human Cells.Species:Human .Predicted Molecular Mass:81.4 KDa. Background:Tie-1/Tie (tyrosine kinase with Ig and EGF homology domains 1) and Tie-2/Tek comprise a receptor tyrosine kinase (RTK) subfamily with unique structural characteristics: two immunoglobulin-like domains flanking three epidermal growth factor (EGF)-like domains and followed by three fibronectin type III-like repeats in the extracellular region and a split tyrosine kinase domain in the cytoplasmic region. These receptors are expressed primarily on endothelial and hematopoietic progenitor cells and play critical roles in angiogenesis, vasculogenesis and hematopoiesis. Human Tie-2 cDNA encodes a 1124 amino acid (aa) residue precursor protein with an 18 residue putative signal peptide, a 727 residue extracellular domain and a 354 residue cytoplasmic domain. Two ligands, angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2), which bind Tie-2 with high-affinity have been identified. Ang-2 has been reported to act as an antagonist for Ang-1. Mice engineered to overexpress Ang-2 or to lack Ang-1 or Tie-2 display similar angiogenesis defects.