Recombinant Human TIM-3 (C-6His)

Description

EnkiLife provides the Recombinant Human TIM-3 (C-6His) protein,aslo know as Hepatitis A Virus Cellular Receptor 2,HAVcr-2,T-Cell Immunoglobulin and Mucin Domain-Containing Protein 3,TIMD-3,T-Cell Membrane Protein 3,TIM-3,HAVCR2,TIM3,TIMD3, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human T-Cell Membrane Protein 3 is produced by our Mammalian expression system and the target gene encoding Ser22-Arg200 is expressed with a 6His tag at the C-terminus.Accession:AAL65157.1. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:20.86 KDa. Background:T-Cell Membrane Protein 3 (TIM3) is a single-pass type I membrane protein that belongs to the TIM family of immunoglobulin superfamily. TIM3 includes a signal sequence (aa 1-21), an extracellular region (aa 22-202) with one Ig-like V-type domain, a transmembrane segment (aa 203-223), and a cytoplasmic domain (aa 224 - 301). TIM3 regulates macrophage activation, inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. It may be also involved in T-cell homing and as a receptor for LGALS9.