Recombinant Human TIM-3 (C-Fc-6His)

Description

EnkiLife provides the Recombinant Human TIM-3 (C-Fc-6His) protein,aslo know as Hepatitis A virus cellular receptor 2,T-cell immunoglobulin and mucin domain-containing protein 3,T-cell membrane protein 3,FLJ14428,KIM-3,Tim-3,TIM3,TIMD3, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human T Cell Immunoglobulin And Mucin Domain-3 is produced by our Mammalian expression system and the target gene encoding Ser22-Arg200 is expressed with a human IgG1 Fc, 6His tag at the C-terminus.Accession:AAL65157.1. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:47.7 KDa. Background:Hepatitis A virus cellular receptor 2（HAVCR2）is a single-pass type I membrane protein and it contains 1 Ig-like V-type (immunoglobulin-like) domain. The protein belongs to the immunoglobulin superfamily, and TIM family of proteins. The protein regulates macrophage activation. It inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. It may be also involved in T-cell homing and it is receptor for LGALS9. CD4 (MIM 186940)-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. TIM3 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice.