Recombinant Human TIMP-1 (C-6His)

Description

EnkiLife provides the Recombinant Human TIMP-1 (C-6His) protein,aslo know as Metalloproteinase Inhibitor 1,Erythroid-Potentiating Activity,EPA,Fibroblast collagenase Inhibitor,Collagenase Inhibitor,Tissue Inhibitor of Metalloproteinases 1,TIMP-1,TIMP1,CLGI,TIMP, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Tissue Inhibitor Of Metalloproteinases 1 is produced by our Mammalian expression system and the target gene encoding Cys24-Ala207 is expressed with a 6His tag at the C-terminus.Accession:P01033. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:21.75 KDa. Background:Tissue Inhibitor of Metalloproteinases 1 (TIMP-1) is a member of TIMP family. The homologous proteins of TIMPs regulate the activity of matrix metalloproteinases (MMPs), including inhibition of active MMPs, proMMP activation, cell growth promotion, matrix binding, inhibition of angiogenesis and the induction of apoptosis. Timp-1 complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. It also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. It is known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13, and MMP-16, without MMP-14.