Recombinant Human Tissue Factor

Description

EnkiLife provides the Recombinant Human Tissue Factor protein,aslo know as Tissue Factor, TF, Coagulation Factor III, Thromboplastin, CD142, F3, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:≤10 EU/mg;Construction:Recombinant Human Tissue Factor is produced by our Mammalian cell expression system and the target gene encoding Ser33-Glu251 is expressed.Accession:P13726. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:23.98 kDa. Background:Full-length tissue factor (TF) is a transmembrane receptor and cofactor for factor (F)VII/FVIIa. In addition to full-length TF, an alternative spliced (as) form of TF can be generated that lacks the transmembrane domain and is released fromcells. In contrast to TF, asTF has low procoagulant activity because it lacks the transmembrane domain. Tissue factor is expressed by cells around blood vessels, such as adventitial fibroblasts, and body surfaces, such as epithelial cells, and plays a critical role in hemostasis. TF also contributes to various forms of thrombosis. Many cancers, particularly adenocarcinomas, express high levels of TF. A high level of tumor TF expression is associated with poor prognosis in many types of cancers, including breast, prostate, colorectal, and pancreatic cancer.