Recombinant Human TL1A (N-mFc)

Description

EnkiLife provides the Recombinant Human TL1A (N-mFc) protein,aslo know as Tumor Necrosis Factor Ligand Superfamily Member 15,TNF Ligand-Related Molecule 1,Vascular Endothelial Cell Growth Inhibitor,TNFSF15,TL1,VEGI, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Tumor necrosis factor ligand superfamily member 15 is produced by ourMammalianexpression system and the target gene encoding Leu72-Leu251 is expressed with a mouse IgG1 Fc tag at the N-terminus.Accession:O95150. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:46.5 KDa. Background:Tumor Necrosis Factor Ligand Superfamily Member 15 (TNFSF15) is a new member of the tumor necrosis factor family. TNFSF15 is predominantly an endothelial cell-specific gene, and recombinant TNFSF15 is a potent inhibitor of endothelial cell proliferation, angiogenesis and tumor growth. TNFSF15 exerts two activities on endothelial cells: early G1 arrest of G0/G1-cells responding to growth stimuli and programmed cell death of proliferating cells. These activities are highly specific to endothelial cells. TNFSF15 is also able to regulate the expression of several important genes involved in angiogenesis. These findings are consistent with the view that TNFSF15 functions as an autocrine cytokine to inhibit angiogenesis and stabilize the vasculature.