Recombinant Human TNF RII (C-6His)

Description

EnkiLife provides the Recombinant Human TNF RII (C-6His) protein,aslo know as Tumor necrosis factor receptor superfamily member 1B,Tumor necrosis factor receptor 2,Tumor necrosis factor receptor type II,p75,p80 TNF-alpha receptor,TBP-2,TBPII,TNFRSF1B,TNFBR,TNFR2, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Tumor Necrosis Factor Receptor II is produced by our Mammalian expression system and the target gene encoding Leu23-Asp257 is expressed with a 6His tag at the C-terminus.Accession:P20333. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:26.2 KDa. Background:Tumor necrosis factor receptor superfamily member 1B is a 461 amino acids protein that belongs to the TNFR (tumor necrosis factor receptor) superfamily characterized by cysteine-rich extracellular domains. It contains 4 TNFR-Cys repeats. TNFRII is expressed in fetal brain. TNFRII is strongly expressed at the cartilage-pannus junction, and plays a major role in a subset of families with multiple cases of rheumatoid arthritis (RA). This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.