Recombinant Human TNF RII (C-mFc)

Description

EnkiLife provides the Recombinant Human TNF RII (C-mFc) protein,aslo know as Tumor necrosis factor receptor superfamily member 1B,TNFRSF1B,Tumor necrosis factor receptor 2,TNF-R2,TNF-RII,Tumor necrosis factor receptor type II,p75,p80 TNF-alpha receptor,CD120b, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Tumor Necrosis Factor Receptor Superfamily Member 1B is produced by our Mammalian expression system and the target gene encoding Pro24-Thr206 is expressed with a mouse IgG1 Fc tag at the C-terminus.Accession:P20333. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:46.44 KDa. Background:Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B) is a member of the tumor necrosis factor receptor superfamily. Human TNF RII contains four cysteinerich repeats in its ECD, which shares 58% and 56% amino acid sequence identity with the mouse and rat orthologs, respectively.TNF RII is expressed predominantly on cells of the hematopoietic lineage, such as T and natural killer cells, as well as on endothelial cells, microglia, astrocytes,neurons, oligodendrocytes, cardiac myocytes, thymocytes, and mesenchymal stem cells.TNF RII binds to the membranebound forms of TNFα and Lymphotoxinα/TNFβ;soluble TNF is thought to signal predominately through TNF RI.Soluble TNF RII is believed to inhibit TNF biological activity by binding TNF thereby preventing it from activating membrane TNF receptors.