Recombinant Human TPP1 (C-6His)

Description

EnkiLife provides the Recombinant Human TPP1 (C-6His) protein,aslo know as Tripeptidyl-Peptidase 1,TPP-1,Cell Growth-Inhibiting Gene 1 Protein,Lysosomal Pepstatin-Insensitive Protease,LPIC,Tripeptidyl Aminopeptidase,Tripeptidyl-Peptidase I,TPP-I,TPP1,CLN2, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Tripeptidyl-Peptidase I is produced by our Mammalian expression system and the target gene encoding Ser20-Pro563 is expressed with a 6His tag at the C-terminus.Accession:AAH14863.1. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:60.35 KDa. Background:Tripeptidyl-Peptidase 1 (TPP1) belongs to the peptidase S53 family. TPP1 is detected in all tissues examined with highest levels in heart and placenta and relatively similar levels in other tissues. TPP1 is lysosomal serine protease with tripeptidyl-peptidase I activity. TPP1 may act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. TPP1 requires substrates with an unsubstituted N-terminus. TPP1 mutations have also been shown to cause neuronal ceroid lipofuscinosis type 2 (CLN2).