Recombinant Human TREM2 (C-mFc)

Description

EnkiLife provides the Recombinant Human TREM2 (C-mFc) protein,aslo know as Triggering receptor expressed on myeloid cells 2,TREM2,Triggering receptor expressed on monocytes 2,TREM-2, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Triggering Receptor Expressed on Myeloid Cells 2 is produced by our Mammalian expression system and the target gene encoding His19-Ser174 is expressed with a mouse IgG1 Fc tag at the C-terminus.Accession:Q9NZC2. Expression Host:Human cells.Species:Human.Predicted Molecular Mass:43.8 KDa. Background:TREM2 is a cell surface receptor of the immunoglobulin superfamily. TREM2 is a type-1 transmembrane protein that shuttles to the plasma membrane where it exerts its cell autonomous biological functions. TREM2 undergoes regulated intramembrane proteolysis (RIP). TREM2 is preferentially expressed in microglia and is functionally required for migration, cytokine release, phagocytosis, lipid sensing, ApoE binding, shielding of amyloid plaques, and microglia proliferation in the brian. Most of the functionally investigated mutations are located within the Ig-like domain of TREM2.