Recombinant Human TSLP R(C-6His)

Description

EnkiLife provides the Recombinant Human TSLP R(C-6His) protein,aslo know as CRL2,CRL2cytokine receptor CRL2 precusor,CRLF2,CRLF2Y,CRLM-2,Cytokine receptor-like 2,cytokine receptor-like factor 2,ILXR,IL-XR,P2RY8/CRLF2 fusion,PCOR1,TSLP R,TSLP receptor,TSLPR, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Cytokine Receptor-Like Factor 2 is produced by our Mammalian expression system and the target gene encoding Gly25/xadLys231 is expressed with a 6His tag at the C-terminus.Accession:Q9HC73. Expression Host:Human Cells.Species:Human .Predicted Molecular Mass:24.8 KDa. Background:Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system. TSLP R expression is ubiquitous in the immune and hematopoietic cells, but is up-regulated in Th2-skewed cells. Cells expressing TSLP R alone bind TSLP with low affinity. Co-expression of TSLP R and IL-7 R alpha is required for high-affinity TSLP binding and signal transduction . The TSLP R and IL-7 R alpha are coexpressed primarily on monocytes and dendritic cells and at lower levels in lymphoid cells. TSLP has been shown to induce the release of T cell-attracting chemokines from monocytes and enhance the maturation of CD11c+ dendritic cells.