Recombinant Human TWEAK R (C-Fc)

Description

EnkiLife provides the Recombinant Human TWEAK R (C-Fc) protein,aslo know as TNFRSF12A,Fibroblast growth factor-inducible immediate-early response protein 14,FN14,CD266 antigen and tweak-receptor, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human TNF-related Weak Inducer Of Apoptosis Receptor is produced by our Mammalian expression system and the target gene encoding Glu28-Trp79 is expressed with a human IgG1 Fc tag at the C-terminus.Accession:Q9NP84. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:32.7 KDa. Background:Tumor necrosis factor receptor superfamily member 12A(TNFRSF12A) is also known as Fibroblast growth factor-inducible immediate-early response protein 14, FN14, CD266 antigen and tweak-receptor. TNFRSF12A is a single-pass type I membrane protein, including a 27 aa signal peptide, a 53 aa extracellular domain, a 21 aa transmembrane domain and a 28 aa cytoplasmic domain. TNFRSF12A is highly expressed in heart, placenta and kidney. TNFRSF12A can be induced by FGF1 and phorbol ester. TNFRSF12A binds to TWEAK/TNFSF12A to initiate a signal transduction cascade, causing different cellular responses such as cell death, cell proliferation, and angiogenesis.