Recombinant Human UCH-L3 (C-6His)

Description

EnkiLife provides the Recombinant Human UCH-L3 (C-6His) protein,aslo know as Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L3,UCH-L3,Ubiquitin Thioesterase L3,UCHL3, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L3 is produced by our E.coli expression system and the target gene encoding Met1-Ala230 is expressed with a 6His tag at the C-terminus.Accession:P15374. Expression Host:E.coli.Species:Human.Predicted Molecular Mass:27.25 KDa. Background:Ubiquitin Carboxyl-Terminal Hydrolases (UCHs) are a family of cysteine hydrolases. They catalyze the hydrolysis of amides, thioesters and esters, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin. Up regulation of UCHL3 is associated with uterine cervical neoplasms. UCHL3 is implicated in age related cognitive disorders. UCHL3 also promotes adipogenesis and insulin signaling. In mice, UCHL3 knockout have been shown to be resistant to diet-induced obesity.