Recombinant Human VEGFB (N-Fc)

Description

EnkiLife provides the Recombinant Human VEGFB (N-Fc) protein,aslo know as Vascular endothelial growth factor B;VEGF-B;VEGF-related factor;VRF, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Vascular Endothelial Growth Factor B is produced by our Mammalian expression system and the target gene encoding Pro22-Ala207 is expressed with a human IgG1 Fc tag at the N-terminus.Accession:P49765. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:45.7 KDa. Background:VEGFB, as known as VRF, is a member of the VEGF family of growth factors that share structural and functional similarity. By alternative splicing, two isoforms of mature VEGF-B containing 167 or 186 amino acid (aa) residues exist. VEGF-B is expressed in most tissues, especially in heart, skeletal muscle and pancreas. The two VEGF-B isoforms have identical amino-terminal cysteine-knot VEGF homology domains but the carboxyl end of VEGF-B167 differs from that of VEGF-B186 by the presence of a highly basic cysteine-rich heparin binding domain. VEGF-B167 and a proteolytically processed form of VEGF-B186 also bind neuropilin-1, a type I transmembrane receptor for semaphorins/collapsins, ligands involved in neuron guidance.