Recombinant Human VSIG4 (C-Fc)

Description

EnkiLife provides the Recombinant Human VSIG4 (C-Fc) protein,aslo know as V-set and immunoglobulin domain-containing protein 4,VSIG4;Protein Z39Ig;Z39IG;CRIg, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human V-Set And Immunoglobulin Domain-Containing Protein 4 is produced by our Mammalian expression system and the target gene encoding Arg20-Val284 is expressed with a human IgG1 Fc tag at the C-terminus.Accession:Q9Y279. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:56.3 KDa. Background:V-set and immunoglobulin domain-containing protein 4(VSIG4) is a transmembrane protein contains a signal peptide, a V-type Ig-like domain, a C2-type Ig-like domain, several potential O-glycosylation sites, and an intracellular domain with 2 potential phosphorylation sites and is structurally related to the B7 family of immune regulatory proteins. This protein is also a receptor for the complement component 3 fragments C3b and iC3b.The main function is strong negative regulator of T-cell proliferation and IL2 production and it is also potent inhibitor of the alternative complement pathway convertases. It abundantly expressed in several fetal tissues such as adult tissues, highest expression in lung and placenta and it also expressed in resting macrophages.