Recombinant Human WISP3 (E. coli)

Description

WNT1-inducible-signaling pathway protein 3 WISP3 is a member of the CCN family of cysteine-rich, glycosylated signalling proteins that mediate several developmental processes, and a member of the WNT1 inducible signalling pathway WISP subfamily. Members of this family are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain IGFBP , von Willebrand factor type C VWFC domain, thrombospondin type-1 repeat TSP type-1 domain, and C-terminal cystine knot-like CTCK domain. WISP3 is expressed in mature and fetal kidneys, testis, and in lower levels in the ovary, placenta, prostate, and small intestine. It is necessary for the growth of postnatal skeleton and cartilage homeostasis.