Recombinant Human ZWINT (N-6His)

Description

EnkiLife provides the Recombinant Human ZWINT (N-6His) protein,aslo know as ZW10 Interactor,ZW10-Interacting Protein 1,Zwint-1,ZWINT, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human ZW10 Interactor is produced by our E.coli expression system and the target gene encoding Met1-Pro277 is expressed with a 6His tag at the N-terminus.Accession:AAI10400.1. Expression Host:E.coli.Species:Human.Predicted Molecular Mass:33.4 KDa. Background:ZW10 Interactor is localized to the kinetochores from late Prophase to Anaphase and has a uniform distribution in the cytoplasm of Interphase cells. ZWINT interacts ZW10, MIS12 and NDC80 subunit of the NDC80 complex specifically during mitosis. ZWINT is a part of the MIS12 complex which is required for kinetochore formation and spindle checkpoint activity. In addition, ZWINT is required to target ZW10 to the kinetochore at prometaphase.