Recombinant K. pneumoniae NEO

Description

EnkiLife provides the Recombinant K. pneumoniae NEO protein,aslo know as Aminoglycoside 3-phosphotransferase,APH(3)-II,APH(3)II,Kanamycin kinase type II,Neomycin-kanamycin phosphotransferase type II,neo, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Klebsiella Pneumoniae Aminoglycoside 3-phosphotransferase is produced by our E.coli expression system and the target gene encoding Met1-Phe264 is expressed.Accession:P00552. Expression Host:E.coli.Species:Klebsiella pneumoniae.Predicted Molecular Mass:29 KDa. Background:Aminoglycoside 3-phosphotransferase (APH(3)), also known as aminoglycoside kinase, is an aminoglycoside-modifying enzyme and widely presented in resistant bacteria. These ATP-dependent enzymes phosphorylate the 3-hydroxyl of a variety of aminoglycosides including kanamycins, neomycins, paromomycins, neamine, ribostamycin, geneticin, and paromamine. These phosphorylated aminoglycosides fail to bind to their respective ribosomal binding sites with high affinity; hence resistance is conferred to the drugs that are phosphorylated. APH(3) is primarily found in certain species of gram-positive bacteria.