Recombinant Mouse ALK-1 (C-Fc)

Description

EnkiLife provides the Recombinant Mouse ALK-1 (C-Fc) protein,aslo know as Serine/threonine-protein kinase receptor R3,SKR3,Activin receptor-like kinase 1,ALK-1,TGF-B superfamily receptor type I,TSR-I,ACVRL1,activin A receptor type II-like 1,activin A receptor, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Mouse Activin Receptor-like Kinase 1 is produced by our Mammalian expression system and the target gene encoding Asp23-Pro119 is expressed with a human IgG1 Fc tag at the C-terminus.Accession:Q61288. Expression Host:Human Cells.Species:Mouse.Predicted Molecular Mass:38.1 KDa. Background:Activin Receptor-Like Kinase 1 (ALK-1) is a type I cell-surface receptor for the TGF-β superfamily of ligands, which mediates signaling of BMP9 (bone morphogenetic protein) and BMP10. ALK1 signaling is necessary for angiogenesis during embryogenesis, wound healing, and tumor growth. ALK-1 has a high degree of similarity in serine-threonine kinase subdomains, a glycine and serine rich region preceding the kinase-domain, and a C-terminal tail with other activin receptor-like kinase proteins. ALK-1 is mainly expressed in endothelial cells regulating proliferation and migration in vitro and angiogenesis in vivo. Mutations in ALK-1 as well as in endoglin are associated with hereditary hemorrhagic telangiectasia (HHT), suggesting ALK-1 plays a critical role for in the control of blood vessel development or repair.