Recombinant Mouse CD157 (C-6His)

Description

EnkiLife provides the Recombinant Mouse CD157 (C-6His) protein,aslo know as ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2,ADP-ribosyl cyclase 2,Antigen BP3,BP-3 alloantigen,Bone marrow stromal antigen 1,BST-1,Cyclic ADP-ribose hydrolase 2,cADPr hydrolase 2,Leukocyte antigen 65,Ly-65,CD157,Bst1,Bp-3,Bp3,Ly65, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Mouse ADP-ribosyl Cyclase/cyclic ADP-ribose Hydrolase 2 is produced by our Mammalian expression system and the target gene encoding Ala25-Glu285 is expressed with a 6His tag at the C-terminus.Accession:Q64277. Expression Host:Human Cells.Species:Mouse.Predicted Molecular Mass:30.3 KDa. Background:CD157 is a glycosyl phosphatidylinositol anchored membrane protein that belongs to the CD38 family. CD157 was discovered in a bone marrow stromal cell line where it facilitates preBcell growth. Along with CD38, CD157 is a bifunctional ectoenzyme that exhibits both ADP-ribosyl cyclase and cyclic ADP ribose hydrolase activities. It may play a role in rheumatoid arthritis (RA) due to its enhanced expression in RA-derived bone marrow stromal cell lines. CD157 has been predicted to function as a cell surface receptor and an immunoregulatory molecule. CD157 was originally identified as a bone marrow stromal cell molecule (BST-1) with a glycosylphosphatidylinositol (GPI) anchor to bind to the cell surface. CD157 is prevalently expressed by cells of the myeloid lineage. CD157 could act as a receptor with signal transduction capability. Further, it regulates calcium homeostasis and promotes polarization in neutrophils and mediates superoxide (O2−) production in the human U937 myeloid line.