Recombinant Mouse CLEC2D (N-6His)

Description

EnkiLife provides the Recombinant Mouse CLEC2D (N-6His) protein,aslo know as C-type lectin domain family 2 member D,C-type lectin-related protein B,Clr-b,Lectin-like transmembrane protein,Osteoclast inhibitory lectin,Clec2d,Clrb,Ocil, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Mouse C-type Lectin Domain Family 2 Member D is produced by our Mammalian expression system and the target gene encoding Leu63-Ser207 is expressed with a 6His tag at the N-terminus.Accession:Q91V08. Expression Host:Human cells.Species:Mouse.Predicted Molecular Mass:17.9 KDa. Background:C-type lectin domain family 2, member D (CLEC2D) is implicated in the immune response. Sensing tissue damage is an ancient function of immune cells that is central to the regulation of inflammation, tissue repair, and immunity. The C-type lectin receptor Clec2d as a sensor of cell death, which directly detects histones released during necrosis and thus contributes to inflammation and immunopathology. The Clec2d pathway may also be exploited to favor a pro-inflammatory anti-tumor response. And tumor cells can show reduced global levels of histone modification, which may favor Clec2d sensing. The contrasting expression of CLEC2D in HIV infection and pre-eclampsia is demonstrative of the immunosuppressive and pro-inflammatory roles of the respective pathologies.