Recombinant Mouse EDA2R (C-6His)

Description

EnkiLife provides the Recombinant Mouse EDA2R (C-6His) protein,aslo know as Ectodysplasin A2 receptor,EDA-A2 receptor,EDA-A2R,Tumor necrosis factor receptor superfamily member XEDAR,Tumor necrosis factor receptor superfamily member 27,X-linked ectodysplasin-A2 receptor;EDAA2R,TNFRSF27,XEDAR;EDAR2, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Mouse Ectodysplasin A2 Receptor is produced by our Mammalian expression system and the target gene encoding Met1-Thr138 is expressed with a 6His tag at the C-terminus.Accession:Q8BX35. Expression Host:Human Cells.Species:Mouse.Predicted Molecular Mass:16.4 KDa. Background:Tumor necrosis factor receptor superfamily member 27, also known as XEDAR and EDA2R, is a type III transmembrane protein of the TNFR superfamily. EDA2R consists of extracellular domain (ECD) with 3 cysteine-rich repeats and a single transmembrane domain but lacks an N-terminal signal peptide. EDA2R is widely expressed, notably in embryonic basal epidermal cells and maturing hair follicles. Even though it does not contain a cytoplasmic death domain, EDA2R can associate with Fas and induce EDA‑A2 dependent apoptosis. Its transcription is directly induced by p53, and it mediated cell death is p53 dependent. it is down‑regulated in breast, colon, and lung cancers, particularly in cases with p53 mutations. It also plays a role in EDA‑A2 induced skeletal muscle degeneration and osteoblast differentiation. Mutations in the EDA gene are associated with the X-linked form of Hypohidrotic Ectodermal Dysplasia (HED), a disease typically characterized by abnormal hair, teeth and sweat glands.