Recombinant Mouse EXTL2 (N-6His)

Description

EnkiLife provides the Recombinant Mouse EXTL2 (N-6His) protein,aslo know as Exostosin-like 2,Extl2,Alpha-1;4-N-acetylhexosaminyltransferase EXTL2,Alpha-GalNAcT EXTL2,EXT-related protein 2,Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Mouse Exostosin-like 2 is produced by our Mammalian expression system and the target gene encoding Asn43-Met330 is expressed with a 6His tag at the N-terminus.Accession:Q9ES89. Expression Host:Human Cells.Species:Mouse.Predicted Molecular Mass:33.6 KDa. Background:Exostosin-like 2 (EXTL2) is a member of the exostosin (EXT)-related family which contains five members: EXT1, EXT2, EXTL1, EXTL2, and EXTL3. Studies have shown that EXT gene family members have the activities of heparan sulfate-synthesizing glycosyltransferases. EXT1 and EXT2, which have been identified as causal genes for hereditary multiple exostoses, have HS-GlcAT-II and GlcNAcT-II activities. EXTL1 has GlcNAcT-II activity and EXTL3 has GlcNAcT-I and -II activities. EXTL2 has GlcNAcT-I and N-acetylgalactosaminyltransferase activities, and transfers a GlcNAc residue to the tetrasaccharide linkage region when this region is phosphorylated by a xylose kinase 1 (FAM20B) and thereby terminate chain elongation. In mice, lack of EXTL2 causes glycosaminoglycan (GAG) overproduction and structural changes of GAGs associated with pathological processes.